Endocrine Abstracts

Introduction: PTH concentrations obtained with the second generation (2G) assays may vary widely according cross-reactivities against 7–84 PTH fragments. 1–84 bio-intact PTH is only measured with a third generation (3G) assay.Objective: To evaluate whether the results found with a 3G method improve the classification of dialysis patients according to the KDIGO recommendations.Patients and methods: We studied the PTH value...

Background: Vitamin D3 is the common supplemented form, vitamin D2 is often provided as prescribed supplement in many countries, such as the USA. In these countries, measuring 25(OH)D in patients treated with vitamin D2 using an assay that measures 25(OH)D2 poorly may confound clinical care. Recently, the ADVIA Centaur vitamin D assay has been commercialized for use in the clinical laboratory. We evaluated the assay’s ability of measuring both 25(OH)D2 and 25(OH)D3 and co...

Vitamin D deficiency causes rickets in children and osteomalacia in adolescents. Rickets cases are still being reported in the Arab gulf area and worldwide. The clinical spectrum ranges from subclinical (asymptomatic) form to severe symptoms and signs including progressive bone pains, myopathy, waddling gait and bone deformities.We recorded the clinical, biochemical and radiological data 50 adolescents with severe vitamin D deficiency. Clinical symptoms ...

Introduction: Disorder of water and electrolyte balance may develop after transsphenoidal (TNS) surgery for pituitary adenomas. In particular, delayed hyponatremia (Na<135 mEq/l) due to SIADH is reported in 8–35% of patients and usually resolves with fluid-intake restriction within 6 days. The possible role of vasopressin-2 receptor antagonists in this clinical setting has not been elucidated.Case report: We report a case of a 57-years-old Cauca...

Several studies have addressed the possible role of leptin, the product of the obesity gene (Ob), in ovarian cancer development and progression. Herein, we used the OVCAR-3 cell line expressed both the long (ObRb) and short (ObRt) isoforms of the mRNAs of the leptin receptor, to analyse the effect of leptin on the expression of selected genes involved in the cell cycle and apoptosis. OVCAR-3 cells were exposed to 2 and 20 ng/ml of leptin (noted in non-obese women) or 40 and 10...

Cystic ovarian disease is a common reproductive disorder in women and females of domestic animals, leading to temporal or permanent infertility. Over one in three women with polycystic ovarian syndrome (PCOS) are overweight and have higher serum leptin concentration. Leptin may thereby mediate some of the adverse effect of obesity on ovarian function.In the presented data, we decided to compare the action of two high doses of leptin (20 ng and 40 ng/ml) ...

The recommended amount of administered radioiodine activity needed to successfully ablate thyroid remnants after total thyroidectomy is controversial. We compared the efficacy of 50mCi and 100mCi radioactive iodine for thyroid remnant ablation among patients with low stage and low to intermediate risk differentiated thyroid cancer who underwent total thyroidectomy through a retrospective cohort study in a tertiary multi-specialty referral center located in Quezon City, Philipp...

Background: Adolescence is a time of change and is associated with a deterioration in glycaemic control. Education is an important part of diabetes care and enables patients to understand how to manage their condition. An audit was carried out to assess whether adolescents with type 1 diabetes were being educated about social aspects of diabetes.Method: Fifteen adolescents between the ages of 13 and 17 were asked to subjectively score their knowledge of ...

Several recent animal studies have revealed that the gonad is particularly sensitive to exposures to endocrine disrupters during the early fetal period, when sex differentiation occurs. Thus exposure to doses of phthalates, which have small or no effects when given to adult rats, can have pronounced effects in male offspring of pregnant rats exposed to the same doses of DEHP and DBP. At certain dose levels the effects include severe dysgenesis of the testis, undescended testis...

The pharmacologic armamentarium available to clinicians to reduce fracture risk in women with postmenopausal osteoporosis consists essentially of antiresorptive agent. Recently, peptides from the parathyroid hormone (PTH) family, which under specific modalities of administration act as anabolic agents have become available. The interest generated by these alternatives to antiresorptive treatment resides in their greater potential for restauration of bone mass and possibly also...